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If this drug is citrate used during pregnancy, or citrate the patient becomes pregnant while taking this drug, or within approximately two months after discontinuing therapy, the patient should be apprised of tamoxifen the potential risks to tamoxifen the fetus including citrate the potential long-term citrate risk of a DES-like syndrome. However, the data from the randomized studies do not suggest an adverse effect. Laboratory Tests: Periodic complete blood counts, including platelet counts, and tamoxifen periodic liver function tests should be obtained. It was reported that some rat pups showed slower learning behavior, but this did not achieve statistial significance in one study, and in another study where significance was reported, this was obtained by comparing dosed animals with controls of another study. Less frequently reported adverse reactions are tamoxifen vaginal bleeding, vaginal discharge, menstrual irregularities and skin rash. Following a single oral dose of 20 mg tamoxifen, an average peak plasma concentration of 40 ng/mL (range 35 to 45 ng/mL) occurred approximately 5 hours after dosing. All other adverse effects occurred with similar frequency in the two treatment groups, with the exception of thrombotic events, which although rare, were more common with Tamoxifen Citrate tamoxifen than with placebo. Survival at 10 tamoxifen years was.5 for tamoxifen. In a large randomized trial in Sweden of adjuvant Tamoxifen Citrate 40 mg/day for 2-5 years, an increased incidence of uterine cancer was noted. If you do not have a dose-measuring device, ask your pharmacist for one. Do not take extra medicine to make up the missed dose. This medicine can pass into body fluids (urine, feces, vomit). Twenty-nine percent were 50 years of age and 71 were / to 50 years. Where such coadministration exists, careful monitoring of the patient's prothrombin time is recommended. Although the clinical relevance of these changes is unknown, some of these changes, especially vaginal adenomas, are similar to those seen in young women who citrate were exposed to diethylstilbestrol in utero and who have a 1 in 1000 risk of developing. When compared to placebo, Tamoxifen Citrate showed a significantly higher incidence of hot flashes (19 versus 8 for placebo). Important information, do not use tamoxifen citrate if you are pregnant. In the nsabp B-14 trial in which patients were randomized to Tamoxifen Citrate 20 mg/day for 5 years versus placebo, the incidence of second primary breast cancers is also reduced. The recommended daily human dose of 20-40 mg corresponds.4-0.8 mg/kg for an average 50 kg woman. Because many drugs are excreted citrate in human milk and because of the potential for serious adverse reactions in nursing infants from Tamoxifen Citrate Tablets, a decision should be made whether to discontinue nursing or to discontinue the drug, taking. A very serious allergic reaction to this drug is rare. If you notice other effects not listed above, contact your doctor or pharmacist. There was a decreased number of implantations, and all fetuses were found dead. Take the missed dose as soon as you remember. Also, in oligospermic males treated with tamoxifen, LH, FSH, testosterone and estrogen levels were elevated. Distributed BY barr laboratories, INC. Top of page, warnings, visual disturbance including corneal changes, cataracts and retinopathy have been reported in patients receiving Tamoxifen Citrate Tablets. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with tamoxifen. Do not take tamoxifen if you are pregnant. If hypercalcemia does occur, appropriate measures should be taken and, if severe, Tamoxifen Citrate Tablets should be discontinued.